Prof Qian Vivian Liu
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Dr. Vivian Qian Liu is an assistant professor at Institute of Parasitology at McGill University since 2020. Her lab studies the entry and assembly of Nipah virus and SARS-CoV-2 by using single-molecule imaging technology. Dr. Liu obtained her Ph.D. degree with Dr. Hector Aguilar-Carreno (now at Cornell) in Infectious Diseases and Immunology at Washington State University in 2014. She did her postdoc with Dr. Keng Chou at the Department of Chemistry at UBC from 2016 to 2020, where she obtained skills on the development of super-resolution microscopy and image analysis. When not in the lab, Dr. Liu spends time with her 3-year-old boy in parks all around Montreal. Before her son was born, Dr. Liu enjoys cooking, swimming, and watching the Cartel TV shows.
The nanoscale organization of Nipah virus matrix protein revealed by super-resolution microscopy
The matrix proteins of many enveloped RNA viruses mediate virus assembly and budding. However, it remains poorly understood how many matrix proteins are involved for virus budding and how they interact with envelope proteins. Here, we show that most extracellular particles containing over 200 copies of NiV-M are produced by autonomous assembly and budding of NiV-M, instead of the physiological activities of host cells. Our data revealed that NiV-M affects the circularity of VLPs while the NiV envelope proteins do not. Additionally, the organization patterns of NiV envelope proteins in VLPs are similar to those on the extracellular vesicle membranes that do not express NiV-M, suggesting that NiV-M does not directly interact with the envelope proteins during assembly and budding.